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KMID : 0359920080270010162
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Korean Journal of Nephrology
2008 Volume.27 No. 1 p.162 ~ p.165
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A Case of Collapsing Glomerulopathy in Renal Allograft
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Kim Ji-Hwan
Jung Jung-IM
Nam Ju-Yeon
Kim Jong-In
Kim Joong-Kyung
Jung Yeon-Soon
Rim Hark
Jung Min-Jung
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Abstract
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Collapsing glomeruopathy (CG) is a clinicopathologic variant of focal segmental glomerulosclerosis (FSGS) and is characterized by severe nephrotic syndrome, rapid progression to end stage renal disease, and features of visceral epithelial cell injury and glomerular capillary collapse. Such characteristics closely resemble those of HIV associated nephropathy. The frequency of CG has increased over the last decade. The cause of CG is unknown. The lesion has rarely been described in renal allografts with features similar to CG in native kidney. We recently identified allograft CG in a 44 year-old male patient who underwent biopsy for graft dysfunction after autodermic graft. The biopsy showed typical characteristics of CG. Serologically, the patient had no evidence of HIV infection. The renal function was not restored to normal in spite of methylprednisolone pulsing therapy. Now he is on conservative treatment with a functioning graft.
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KEYWORD
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Focal segmental glomerulosclerosis (FSGS), Nephrotic
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